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Search Results for " neutral endopeptidase "

32

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1176	Racecadotril Acetorphan,消旋卡多曲	Neprilysin; Proteasome	Metabolism; Proteases/Proteasome; Ubiquitination
	Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂，具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性，Ki 分别为 4500 和 6.1 nM。
T7693	Thiorphan	Neprilysin	Metabolism
	Thiorphan 是选择性neprilysin 抑制剂 (IC50:6.9 nM) 。
TQ0106	Sacubitrilat LBQ-657	Neprilysin	Metabolism
	Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。
T4574	Sacubitril AHU 377,AHU377,沙库必曲,AHU-377	Neprilysin	Metabolism
	Sacubitril (AHU-377) 是一种有效的NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T4200	Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt	Neprilysin	Metabolism
	Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T10918	NEP-IN-1	Neprilysin	Metabolism
	NEP-IN-1 是中性肽链内切酶 (NEP) 的抑制剂 (IC50 = 2 nM)。
T19626	LHW090-A7 (ALPHAS)-3'-氯-ALPHA-[[(1S)-2-乙氧基-1-甲基-2-氧代乙基]氨基][1,1'-联苯]-4-丙酸	Neprilysin	Metabolism
	LHW090-A7 是一种中性肽链内切酶 (NEP) 抑制剂，是一种负责脑啡肽代谢失活的酶。
T27119L	(Rac)-Daglutril SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid	Others	Others
	(Rac)-Daglutril (SLV 306 acetic acid) 是 Daglutril 的消旋体。Daglutril 是一种口服活性的混合中性内肽酶/内皮素转化酶抑制剂，正在开发用于治疗原发性高血压和充血性心力衰竭。
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor	GPCR/G Protein
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。
T10671	Candoxatril UK 79300	Others	Others
	Candoxatril is an inhibitor neutral endopeptidase (NEP).
T23698	Aladotril BP1137,BP 1137,BP-1137
	Aladotril is an inhibitor of neutral endopeptidase. Its prodrug is aladotrilat.
T12994	SQ28603 Squibb 28603,SQ28,603	Others	Others
	SQ28603 is a potent and selective neutral endopeptidase 3.4.24.11 (NEP) inhibitor.
T29053	UK-447841 UK 447841
	UK-447841, a neutral endopeptidase (NEP) inhibitor, is used potentially for the treatment of female sexual dysfunction.
T28715	Sch 34826 Sch34826,Sch-34826
	Sch 34826 is a potent, selective neutral endopeptidase inhibitor.
T70567	CGS 25462
	CGS 25462 is a neutral endopeptidase (NEP) inhibitor.
T23699	Aladotrilat Fasidotrilat
	Aladotrilat is an inhibitor of neutral endopeptidase. Its prodrug is aladrotril.
T70471	Cgs 26303
	Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation.
T31598	Ecadotril S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049
	Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role.
T70698	MDL-100173
	MDL-100173 is a dual angiotensin-converting enzyme (ACE)/neutral endopeptidase (NEP) inhibitor.
T26048	RB 101 RB101,RB-101
	RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.
T30701	Candoxatrilat UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578
	Candoxatrilat (U 73967, UK69578) is an active neutral endopeptidase inhibitor that reduces atrial natriuretic peptide degradation.
T29052	UK-414,495 UK 414495,UK414,495,UK414495,UK-414495
	UK-414,495 is a potent, selective inhibitor of the neutral endopeptidase, the enzyme normally serves to break down the neuropeptide VIP.
T15696	NEP-IN-2	Others	Others
	NEP-IN-2 is an inhibitor of neutral endopeptidase. It also is used in the research of proliferation in atherosclerosis, restenosis.
T68601	Azidothiorphan
	Azidothiorphan is a photoaffinity ligand for the active site of the neutral endopeptidase 24.11. After ultraviolet irradiation the inhibitor binds irreversibly to the enzyme, and photolabeling occurs at the active site. The competitive inhibitor thiorphan protects the endopeptidase from inactivation.
T16840	Sampatrilat UK-81252	Others	Others
	Sampatrilat is an effecive and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase. Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM).
T37890	GLP-1(28-36)amide
	GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it effectively inhibits mitochondrial permeability transition (MPT). This compound exhibits anti-diabetic properties and demonstrates cardioprotection effects[1].
TP1917	Sar-[D-Phe8]-des-Arg9-Bradykinin
	Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
T61095	SCH-42354
	SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP), serving as the active form of the prodrug SCH-42495. By inhibiting NEP hydrolysis, SCH-42354 enhances the activity of atrial natriuretic peptide (ANP) and prevents the hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. Furthermore, SCH-42354 exhibits antihypertensive activity [1] [2].
T36943	Aminopeptidase N Inhibitor
	Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.
T81444	PL-3994
	PL-3994作为NPR-A的激动剂，展现了对中性肽酶的耐药特性，具有支气管扩张效应。对预收缩豚鼠气管，PL-3994表现出浓度依赖性的弛豫作用，其IC50值为42.7 nM。
T76191	GLP-1(28-36)amide TFA
	GLP-1(28-36)amide TFA，为GLP-1 C-端九肽段，主要通过中性内肽酶（NEP）裂解GLP-1生成。该化合物作为一种抗氧化剂，能靶向线粒体，抑制线粒体通透性转变（MPT），显示出抗糖尿病和心脏保护的功效。

化合物

Cat.No: T1176

Synonym: Acetorphan,消旋卡多曲

Target: Neprilysin, Proteasome

Cat.No: T7693

Target: Neprilysin

Cat.No: TQ0106

Synonym: LBQ-657

Target: Neprilysin

Cat.No: T4574

Synonym: AHU 377,AHU377,沙库必曲,AHU-377

Target: Neprilysin

Sacubitril hemicalcium salt

Cat.No: T4200

Synonym: AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt

Target: Neprilysin

Sacubitril/Valsartan

Cat.No: T2318

Synonym: Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696

Target: Apoptosis, RAAS, Neprilysin

Cat.No: T10918

Target: Neprilysin

Cat.No: T19626

Synonym: (ALPHAS)-3'-氯-ALPHA-[[(1S)-2-乙氧基-1-甲基-2-氧代乙基]氨基][1,1'-联苯]-4-丙酸

Target: Neprilysin

(Rac)-Daglutril

Cat.No: T27119L

Synonym: SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid

Target: Others

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

Cat.No: TP1917L1

Synonym: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)

Target: Bradykinin Receptor

Cat.No: T10671

Synonym: UK 79300

Target: Others

Cat.No: T23698

Synonym: BP1137,BP 1137,BP-1137

Cat.No: T12994

Synonym: Squibb 28603,SQ28,603

Target: Others

Cat.No: T29053

Synonym: UK 447841

Cat.No: T28715

Synonym: Sch34826,Sch-34826

Cat.No: T70567

Cat.No: T23699

Synonym: Fasidotrilat

Cat.No: T70471

Cat.No: T31598

Synonym: S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049

Cat.No: T70698

Cat.No: T26048

Synonym: RB101,RB-101

Cat.No: T30701

Synonym: UK69578,UK 69578,U 73967,U-73967,U73967,UK-69578

Cat.No: T29052

Synonym: UK 414495,UK414,495,UK414495,UK-414495

Cat.No: T15696

Target: Others

Cat.No: T68601

Cat.No: T16840

Synonym: UK-81252

Target: Others

GLP-1(28-36)amide

Cat.No: T37890

Sar-[D-Phe8]-des-Arg9-Bradykinin

Cat.No: TP1917

Cat.No: T61095

Aminopeptidase N Inhibitor

Cat.No: T36943

Cat.No: T81444

GLP-1(28-36)amide TFA

Cat.No: T76191

Cat. No.	Product Name	Target	Signaling Pathways
T6627	Phosphoramidon Disodium Phosphoramidon Disodium Salt,磷酰胺二钠	RAAS; Neprilysin; Others	Endocrinology/Hormones; Metabolism; Others
	Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ，中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ，0.034 和 78 μM。
T1168	Desonide Tridesilon,地索奈德,Locapred,Prednacinolone	Glucocorticoid Receptor	Endocrinology/Hormones
	Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂，能够作用于糖皮质激素受体。

天然产物

Phosphoramidon Disodium

Cat.No: T6627

Synonym: Phosphoramidon Disodium Salt,磷酰胺二钠

Target: RAAS, Neprilysin, Others

Cat.No: T1168

Synonym: Tridesilon,地索奈德,Locapred,Prednacinolone

Target: Glucocorticoid Receptor

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